The Genetic Code Sucks. Let’s Do Better

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Your genetic code is neat, but could be better!

Hosted by: Hank Green

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Sources:
Mukai et al. 2017 “Rewriting the Genetic Code”
Chin 2014 “Expanding and Reprogramming the Genetic Code of Cells and Animals”


Khan Academy “Intro to gene expression (central dogma)”
el-Showk 2014 “The Language of DNA”
D’Onofrio and Abel 2014 “Redundancy of the genetic code enables translational pausing”
Spencer and Barral 2012 “Genetic code redundancy and its influence on the encoded polypeptides”
Duton 1983 “The significance of redundancy in the genetic code”
Sleiman et al. 2021 “A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes”
Bain et al. 1992 “Ribosome-mediated incorporation of a non-standard amino acid into a peptide through expansion of the genetic code”
Zhang et al. 2017 “A semisynthetic organism engineered for the stable expansion of the genetic alphabet”
Hoshika et al. 2019 “Hachimoji DNA and RNA: A genetic system with eight building blocks”
Ernst et al. 2016 “Genetic code expansion in the mouse brain”
Robertson et al. 2021 “Sense codon reassignment enables viral resistance and encoded polymer synthesis”
Bethencourt 2009 “Virus stalls Genzyme plant”
Jason Chin: "Reprogramming the genetic code"
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